Indicadores antropométricos e o nível de atividade física associados à Síndrome Metabólica, resistência à insulina e função das células B Pancreáticas em adolescentes

Abstract

Resumo: Objetivo: verificar se indicadores antropometricos e NAF podem estar associados a RI e funcao de CP-ƒÀ em adolescentes. A amostra foi constituida de 173 sujeitos sendo, 79 do sexo masculino e 94 do sexo feminino, todos alunos de escolas publicas da cidade de Curitiba. Massa corporal (MC), estatura (EST), IMC, circunferencia abdominal (CA), RCE, dobras cutaneas e estagio maturacional foram avaliados, foi realizada uma estimativa do NAF atraves de um questionario recordatorio de tres dias. Amostras de 10 mL de sangue foram coletadas apos 12 horas de jejum, a fim de estimar os valores do pefil lipidico, glicemico e hormonio da insulina em jejum. O metodo de avaliacao homeostatica conhecido como (HOMA) foi utilizado para verificar a resistencia a insulina (HOMA-IR) e capacidade funcional das celulas ƒÀ pancreaticas (HOMA- ƒÀ). Para verificar a associacao entre as variaveis foi utilizado o modelo de regressao binaria logistica Odds-ratio com intervalo de confianca de 95% e p<0,05. Deste modo, foram incluidos no estudo somente adolescentes que estavam no estagio 2, 3 e 4 de Tanner (1962). Para o sexo masculino, verificamos associacoes do HOMA-IR com RCE (OR=0,47 p=0,02), ƒ° de Dobras (Tri+Sub) (OR=0,48 p=0,02), e com o NAF(OR=-1,78 p=0,01),.Com relacao ao indice HOMA- ƒÀ foram encontradas associacoes com o EP (OR=0,34 p=0,01), e RCE (OR=0,38 p=0,01). No sexo feminino, ocorreram associacoes do HOMA-IR com a obesidade(OR=2,18 p=0,04), RCE (OR=1,57 p=0,01), ƒ° de Dobras (Tri+Sub) (OR=1,60 p=0,03), % de Gordura(OR=1,80 p=0,01), e HDL-c (OR= -1,79 p=0,01),. Para o HOMA- ƒÀ verificaram-se associacoes com a obesidade(OR=2,28 p=0,02), RCE (OR=1,40 p=0,04), ƒ° de Dobras (Tri+Sub) (OR1,64 p=0,01), e NAF (1,38 p=0,04). Concluimos que os indicadores antropometricos, bem como o NAF de adolescentes apresentam associacoes significativas com as variaveis metabolicas de resistencia a insulina e funcao de celulas ƒÀ pancreaticas em adolescentes puberes.

Abstract: To verify the relationship of anthropometric indicators and physical activity level with insulin resistance and pancreatic â cell function, are extremely important especially in adolescents where the period of puberty is known to increase insulin resistance and impairing glucose homeostasis in the body. Thus, this study aimed to verify if anthropometrics indicators and physical activity level may be associated with insulin resistance and pancreatic â-cell function in adolescents. The sample was composed of 173 subjects, 79 boys and 94 girls, all public school students in the Curitiba city. Weight, height, BMI, waist circumference, WHR, skinfolds and maturational stage were evaluated, there was an estimate of the physical activity level through a threedays diet record. Samples of 10 mL of blood were collected after 12 hours of fasting, in order to estimate the values of lipid profile, fasting glucose and insulin hormone. The evaluation method known as homeostasis (HOMA) was used to assess insulin resistance (HOMA-IR) and functional capacity of pancreatic â-cells (HOMA-â). To test the association between variables was used binary logistic regression model, odds-ratios with confidence interval 95% p<0.05. Thus, in the study were included only adolescents who were in stage 2, 3 and 4 of Tanner (1962). For boys, we found associations of the HOMA-IR with RCE, Ó skinfolds (Tri + Sub) and the PAL. In relation to HOMA-â associations were found with the overweight and WHR. In females, there were associations of HOMA-IR with obesity, WHR, Ó Fold (Tri + Sub),% Fat and HDL-c. For HOMA-â there were associations with obesity, RCE, Ó skinfolds (Tri + Sub) and PAL. We conclude that the anthropometric indicators and the PAL of adolescents have significant associations with metabolic variables of insulin resistance and pancreatic â-cell function in puberty adolescents.